Pharmacogenomics: Difference between revisions
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imported>Robert Badgett (New page: '''Pharmacogenomics''', or '''pharmacogenetics''', is the "branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism (biotransformati...) |
imported>David E. Volk m (subpages) |
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'''Pharmacogenomics''', or '''pharmacogenetics''', is the "branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism (biotransformation)."<ref name="MeSH-pharmacogenetics">{{cite web |url=http://www.nlm.nih.gov/cgi/mesh/2008/MB_cgi?term=Pharmacogenomics |title=Pharmacogenetics |accessdate=2008-01-22 |author=Anonymous |authorlink= |coauthors= |date= |format= |work= |publisher=National Library of Medicine |pages= |language= |archiveurl= |archivedate= |quote=}}</ref> | '''Pharmacogenomics''', or '''pharmacogenetics''', is the "branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism (biotransformation)."<ref name="MeSH-pharmacogenetics">{{cite web |url=http://www.nlm.nih.gov/cgi/mesh/2008/MB_cgi?term=Pharmacogenomics |title=Pharmacogenetics |accessdate=2008-01-22 |author=Anonymous |authorlink= |coauthors= |date= |format= |work= |publisher=National Library of Medicine |pages= |language= |archiveurl= |archivedate= |quote=}}</ref> | ||
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==References== | ==References== | ||
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Revision as of 09:00, 23 January 2008
Pharmacogenomics, or pharmacogenetics, is the "branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism (biotransformation)."[1]
Drug toxicity
Among drugs frequently cited in adverse drug reactions, 60% are metabolized by enzymes with genetic variations in metabolism. 7% to 22% of randomly selected have such variation.[2]
Drug efficacy
Heart failure and hypertension may be an examples were there are racial variations in responses to drugs. Presumably these variations are due to pharmacogenomics.
References
- ↑ Anonymous. Pharmacogenetics. National Library of Medicine. Retrieved on 2008-01-22.
- ↑ Phillips KA, Veenstra DL, Oren E, Lee JK, Sadee W (2001). "Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review". JAMA 286 (18): 2270–9. PMID 11710893. [e]