Azlocillin: Difference between revisions
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Latest revision as of 07:01, 15 July 2024
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Azlocillin is an antibiotic, -lactam drug used to treat infections. It is an acylated form of ampicillin and is similar to the antibiotics mezlocillin and piperacillin. It has greater antibacterial activity relative to similar carboxy forms of penicillin. It is active against a wide variety of bacteria.
Mechanism of action
Amoxicillin binds to the penicillin-binding protein 1A (PBP-1A) located inside the bacterial cell well. It inhibits the last stage of bacterial cell wall synthesis by acylating the penicillin-sensitive transpeptidase C-terminal domain thereby stopping the cross-linking of peptidoglycan strands. Autolytic enzymes in the bacteria then lyse the cells.
Chemistry
Azlocillin is a -lactam drug and is thus susceptible to degration by -lactamase. Its chemical name is (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[[2-[(2-oxoimidazolidine-1-carbonyl)amino]-2-phenylacetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid and it has chemical formula C20H23N5O6S.
External links
The most up-to-date information about Azlocillin and other drugs can be found at the following sites.
- Azlocillin - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Azlocillin - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Azlocillin - Detailed information from DrugBank.