View source for User talk:Pierre-Alain Gouanvic

{{Usertime-text|Pierre-Alain}}{{Template:Utc|19}}  <hr> '''Feel free to use Email for quick responses, until late evenings.'''<hr>
{{awelcome}} --[[User:Larry Sanger|Larry Sanger]] 00:35, 17 August 2007 (CDT)

==Interesting==
Interesting bio on your userpage, Pierre.  Nice to you around, and let me know if I can ever assist you with things around here. [[User:Stephen Ewen|Stephen Ewen]] 16:51, 13 November 2007 (CST)

== Welcome and thanks ==
I'm just spending some time this morning thanking the newer/returned people who have been doing work on the wiki lately.  So, thanks, nice to have you here! --[[User:Larry Sanger|Larry Sanger]] 09:39, 17 November 2007 (CST)

== good info ==

Hi Pierre, I just saw [http://en.citizendium.org/wiki?title=Talk%3AEvidence-based_medicine&diff=100212209&oldid=100212021 your discussion]  on [[Talk:Evidence-based medicine]].  That is a good analysis and good point that should be in the article.  Why don't you see if you can squeeze it in somewhere. --D. Matt Innis 00:43, 18 November 2007 (CST)

== Potassium ==

Pierre-Alain: Yes, the article needs a discussion of potassium and the metabolic syndrome. Thanks for starting and stimulating that topic.  I haven't had a chance to look at [[Metabolic syndrome]] yet but will try to do so soon.  --[[User:Anthony.Sebastian|Anthony.Sebastian]] [[User talk:Anthony.Sebastian|(Talk)]] 22:25, 22 November 2007 (CST)
: I have been working intensely on the Vitamin C page and left the metabolic syndrome with many deficiencies... The reason why I put the MS article aside for a while? 
: '''''Several competing definitions of metabolic syndrome are in use, and each is differently linked to the presence of insulin resistance. These definitions include that of the National Cholesterol Education Program (NCEP) Third Adult Treatment Panel (ATP III) (2), the International Diabetes Federation (IDF) (3), and the European Group for the Study of Insulin Resistance (EGIR) (4). The EGIR definition requires the presence of insulin resistance plus any two other metabolic traits; ATP III and IDF definitions require at least three metabolic traits but do not require the presence of insulin resistance. In studies of ATP III metabolic syndrome, as many as half of subjects do not have insulin resistance (5–7).
'''''
: [http://care.diabetesjournals.org/cgi/content/full/30/5/1219 Impact of Insulin Resistance on Risk of Type 2 Diabetes and Cardiovascular Disease in People With Metabolic Syndrome. James B. Meigs & al, Diabetes Care 30:1219-1225, 2007]. 
: I don't like that. This reminds me of some nightmares I went through as a terminologist. I think that I'll leave MS (and other "clusters" for that matter) for a while and focus on insulin (resistance), ascorbate, SOD, oxidative stress, magnesium, potassium, exercise, adipocyte, many other things, but mostly basic building blocks of knowledge. 
: I have read [http://www.biomedcentral.com/1471-2148/7/61 BMC Evol Biol. 2007 Apr 17;7:61. Evolutionary origins of insulin resistance: a behavioral switch hypothesis. Watve MG, Yajnik CS] Very enlightening and challenging. [[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 00:15, 23 November 2007 (CST)

:: I seriously consider the idea that the metabolic syndrome page should be a very concise page describing the current disagreement and pointing to related pages: insulin resistance, CHD, hypertension, etc. There might be no other way to be objective. 
:: It seems more logical and ethical to cluster conditions in function of common pathophysiological features (magnesium, potassium deficiency, C-reactive protein, etc, etc.) than in function of power struggles between specialists fighting with statistics devoid of any underlying physiological meaning.  [[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 00:31, 23 November 2007 (CST)

==[[Lavigueur family]]==
Hi. I thought this article might be interesting to you. :-) -- [[User:Hugo Voisard|Hugo Voisard]] 16:06, 1 December 2007 (CST)
: Inspiring. ;-) 
: I'm getting a little worried about what people are going to think about quebecers... Let's write articles about Celine, Cirque du Soleil and Denys Arcand! Quick! 
: --[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 16:21, 1 December 2007 (CST)
::Yeah. That's right, so far I've written articles that might that might give a bad opinion of Quebeckers (not my intention though!). So we should find something cool and positive to write about. There is this other article about [[terminological database]]s I wrote (including a section on GDT). I'll see what else I can do. :-) -- [[User:Hugo Voisard|Hugo Voisard]] 13:58, 4 December 2007 (CST)

== Vitamin C ==

Hi again, Pierre-Alain,

I removed the redirect from [[ascorbic acid]] per your comments at [[talk: vitamin C]].  So, come on over to the [[CZ:Monthly Write-a-Thon|write-a-thon]] and start separating, else I'm going to look like an idiot!  [[User:Aleta Curry|Aleta Curry]] 15:52, 4 December 2007 (CST)

Hi Pierre-Alain!

I'm new in Citiz and not very good in english language, so did You can to do all need procedures for Archive:New Draft of the Week - page? :-) [[User:Alexander N. Alexandrov|Alexander N. Alexandrov]] 02:45, 5 December 2007 (CST)
: Okay! for what page is it? --[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 10:25, 5 December 2007 (CST)
::For [[Ascorbic acid]] in first case... [[User:Alexander N. Alexandrov|Alexander N. Alexandrov]] 10:40, 5 December 2007 (CST)
::: I wasn't sure. I wonder if it would be possible to modify it a little bit more before it is submitted to the vote. I'll do as you ask me, but I'm worried that unmodified wikipedia content might be taken as a "non-draft". What do you think? Do I understand well the situation? I'm not totally sure what the draft of the week is about. I saw that the next vote will take place tomorow, and the other one the other thursday. This would leave some time to review and edit content. But again, this is only a sympathetic comment, not a "no"! --[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 11:29, 5 December 2007 (CST)
::::Of course You wright...
::::I think this is some about anonce for "together week-work on the article" 
::::It's my fault... Festina lente :-( [[User:Alexander N. Alexandrov|Alexander N. Alexandrov]] 09:49, 8 December 2007 (CST)
:::::I'll do my best to help in the development of this article. I'm afraid, however, that some technical issues are beyond my grasp -- for now. However, I can help a little with style and syntax, etc. English is not my first language either, however... You go first (on the ascorbic acid article), okay? ;-) --[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 12:33, 8 December 2007 (CST)

== Parts that should be reworked in the Vit C page (next two sections (8 and 9)) ==

== Sociology ==
To fully comprehend the special perception that vitamin C enjoys, we must understand the role of Linus Pauling, one of the principal founders of modern chemistry, in the dissemination and popularization of information about this molecule. 

Pauling, a two-time Nobel Prize winner who had received worldwide praise for his work on a common metabolic disease, [[sickle cell anemia]], struggled for the recognition of an even more common metabolic disease, which was termed by OMIM our "public inborn error of metabolism." The response of the medical profession, by Pauling's account, was "astonishing."<ref name="It's in the Bloodp42">{{cite web |url=http://osulibrary.oregonstate.edu/specialcollections/coll/pauling/blood/narrative/page42.html |title=Narrative - Page 42 - It's in the Blood!: A Documentary History of Linus Pauling, Hemoglobin and Sickle Cell Anemia - Special Collections - Oregon State University |accessdate=2007-11-25 |format= |work=}}</ref> From being perhaps the major figure in modern chemistry, Pauling suddenly became, in the eyes of some, little more than a well-meaning but misguided eccentric or even a quack.<ref name="pmid9818798"/><ref name="It's in the Blood Comic featuring Linus Pauling">{{cite web |url=http://osulibrary.oregonstate.edu/specialcollections/coll/pauling/blood/pictures/how.to.live.longer-pg235.html |title=Comic featuring Linus Pauling in the lab. It's in the Blood! A Documentary History of Linus Pauling, Hemoglobin and Sickle Cell Anemia |accessdate=2007-11-25 |format= |work=}}</ref> Meanwhile, masses began to follow Pauling's advice in what became one of the most important movements of citizen science; when asked how to assess the value of the safety warnings and the skeptical responses issued by medical authorities, he responded: "I would trust the biochemistry of a goat over the advice of a doctor." 

[[Image:Galileo facing the Roman Inquisition.jpg|right|thumb|300px|{{#ifexist:Template:Galileo facing the Roman Inquisition.jpg/credit|{{Galileo facing the Roman Inquisition.jpg/credit}}<br/>|}}Galileo, a "dangerous enemy" of the elites, committed the crime of writing for the masses.]]
Goodwin and Tangum draw an interesting analogy with another case in the history of science. Based on the analysis by Giorgio de Santillana of Galileo's impact in XVIIth century Italy, Goodwin and Tangum proposed to their fellow doctors, in [[American Medical Association]]'s ''[[Archives of Internal Medicine]]'', that Pauling's crime, like Galileo's, was not so much that he proposed a new paradigm, but that he proposed it directly to the people.<ref name="pmid9818798">{{cite journal |author=Goodwin JS, Tangum MR |title=Battling quackery: attitudes about micronutrient supplements in American academic medicine |journal=Arch. Intern. Med. |volume=158 |issue=20 |pages=2187–91 |year=1998 |pmid=9818798 |url=http://www.awsc07100.pwp.blueyonder.co.uk/BestBetDietBook/goodwin1.pdf}}</ref> Pauling, by speaking to the population, just like he did when he fought to stop nuclear bomb trials (his success led him to receive his second Nobel Prize), committed the same crime as Galileo, who had chosen to write in the language of the masses (Italian), and who had to face the ire of the "scholarly elite, whom he had bypassed, usurped, and rendered irrelevant". They comment: 
''<blockquote>Of course, (speaking directly to the public) was precisely the course followed by many of the proponents of the benefits of micronutrients, the most famous of whom was Linus Pauling, the chemist who intruded into clinical matters. It is instructive to reread the review articles and editorials published in the 1970s ridiculing and condemning the ideas of Pauling. He was treated as a dangerous enemy, although a few years before his death, like Galileo, he was rehabilitated to the status of a genius with controversial ideas.
</blockquote>''
In effect, Pauling initiated one of the most significant critiques of the medical institution, perhaps even greater than Ivan Illich's critique.<ref name="pmid14652255">{{cite journal |author=Scott-Samuel A |title=Less medicine, more health: a memoir of Ivan Illich |journal=J Epidemiol Community Health |volume=57 |issue=12 |pages=935 |year=2003 |pmid=14652255 |doi=}}</ref> 

By his own admission, Pauling's impetus was to communicate, as an educated citizen, the knowledge amassed by Irwin Stone, Abram Hoffer, Frederick Klenner and others before him. Pauling's "telescope" was his ability to read the literature that had been ignored by what could be called the ''pathocentric'' paradigm.

In the preface of ''The Healing Factor, Vitamin C Against Disease'', Stone's main opus, Pauling summarized: 
<blockquote>''As man has spread over the earth and increased in number, the supplies of ascorbic acid have decreased. It is possible that most people in the world receive only one or two percent of the amounts of ascorbic acid that would keep them in the best of health.  The resulting hypoascorbemia may be responsible for many of the illnesses that plague mankind.''<ref name="The Healing Factor"/></blockquote>
to what Albert Szent-Gyorgyi, the discoverer of vitamin C, added: 
<blockquote>''The medical profession itself took a very narrow and wrong view. Lack of ascorbic acid caused scurvy, so if there was no scurvy there was no lack of ascorbic acid. Nothing could be clearer than this. The only trouble was that scurvy is not a first symptom of lack but a final collapse, a premortal syndrome, and there is a very wide gap between scurvy and full health. But nobody knows what full health is! This could be found out by wide statistical studies, but there is no organization which could and would arrange such studies.''<ref name="The Healing Factor"/></blockquote>

While the debate about the most "luminously controversial of all biological, alternative cancer therapies" is slowly resolving, and as Pauling is regaining his reputation, the philosophical questions raised by the Nobel laureates, that every Human may ask, remain largely unaddressed: where is man coming from? what is health?

'''Replication of positive results''' (presently under revision)

Shortly after the discovery of vitamin C, Jungeblut provided evidence suggesting that it had a broad spectrum antiviral activity, notably against the [[poliomyelitis virus]]. [[Sabin]], who later developed the famous oral [[vaccine]] against polio, attempted to replicate the studies but failed to replicate them, despite of the instructions provided by Jungeblut. It was interpreted as a therapeutic failure of vitamin C. Nonetheless, more than seventy years later, Jungeblut is remembered by specialists as an authoritative source on the antiviral activity of vitamin C, while Sabin is not.(ref: harakeh & jariwalla; '''fix this reference''') '''''In progress''''' ''However, these specialists ...''

[[Evidence-based medicine]] and the [[randomized controlled trial]] (RCT) are intended to free clinical practice from the empire of opinion.<ref name="pmid16227668">{{cite journal |author=Brody H ''& al.'' |title=Evidence-based medicine: watching out for its friends |journal=Perspect. Biol. Med. |volume=48 |issue=4 |pages=570–84 |year=2005 |pmid=16227668 |doi=10.1353/pbm.2005.0085}}</ref> Moertel, who conducted the two RCTs designed to assess Pauling and Cameron's claims about vitamin C, anticancer effects, described himself as a researcher ''combatting/...'' "uncontrolled quackery",<ref name="The Vitamin C and Cancer Controversy">{{cite web |url=http://sss.sagepub.com/cgi/content/abstract/18/4/653 |title=The Politics of Therapeutic Evaluation: The Vitamin C and Cancer Controversy -- Richards 18 (4): 653 -- Social Studies of Science |accessdate=2007-12-09 |format= |work=}}</ref> According to Pauling, who, like Jungeblut, tried to help his colleague, Moertel was unwilling to replicate the study. To be revised: ''"crude EBM practitioners (going) about using their favorite RCTs as clubs with which to beat up their supposedly less-informed colleagues."<ref name="EBM watching out for its friends">{{cite journal |author=BRODY Howard ; MILLER Franklin G. ; BOGDAN-LOVIS Elizabeth |title= Evidence-based medicine : watching out for its friends|journal=Perspectives in biology and medicine |volume= 48|issue=4 |pages=570-584 |year=2005 |pmid= |url=http://www.med.ufl.edu/oea/opfd/faculty/club_med/ebmarticle1.pdf}}</ref> Still today, randomized controlled trials of controversial methodology abound, and allow "crude EBM practicioners" chasing quackery and self-medication to "avoid blame by wrapping themselves in the EBM mantle." Scientific criticisms based on strong pharmacokinetic evidence are responded to with non-scientific non-arguments ("(we are not) ''persuaded'' by the arguments of (...) critics that frequent large doses would necessarily result in substantially greater benefits"): in a paradoxical turn of events, the very behaviour that EBM was intended to minimize, guess work, is magnified and swiftly transmitted to the mass media as uncorruptible truth emanating from the golden standard of biomedical sciences. 

''The mass media, in turn, shape the opinion of the only stakeholders in vitamin C research, the citizens, who gradually cease to reclaim more research and abdicate to private interests the duty to determine what is best for them. And, since "the large quantities of trial data required to meet the standards of evidence based medicine are available for relatively few interventions" this restrictive or "crude" version of evidence-based medicine" does "introduce a systematic bias, resulting in allocation of resources to those treatments for which there is rigorous evidence of effectiveness, or towards those for which there are funds available to show effectiveness (such as new pharmaceutical agents)."<ref name="pmid9552959">{{cite journal |author=Kerridge I, Lowe M, Henry D |title=Ethics and evidence based medicine |journal=BMJ |volume=316 |issue=7138 |pages=1151–3 |year=1998 |pmid=9552959 |doi=}}</ref> and "impinges on the ethical principle of justice."<ref name="pmid15082809">{{cite journal |author=Ernst E, Cohen MH, Stone J |title=Ethical problems arising in evidence based complementary and alternative medicine |journal=J Med Ethics |volume=30 |issue=2 |pages=156–9 |year=2004 |pmid=15082809 |doi=}}</ref>''

''Citizens, philosophers of sciences and ethicists have been called to duty in the struggle for accountability in biomedical sciences.<ref name="pmid9552959"/> The contestation of EBM, which is reaching unprecedented intensity,<ref name="pmid17683283">{{cite journal |author=Miles A, Loughlin M, Polychronis A |title=Medicine and evidence: knowledge and action in clinical practice |journal=J Eval Clin Pract |volume=13 |issue=4 |pages=481–503 |year=2007 |pmid=17683283 |doi=10.1111/j.1365-2753.2007.00923.x}}</ref> is increasingly involving citizens and [[expert patients]], as well as doctors who decide to publicly express their fear that "the next generation of doctors (is) being conditioned to function like a well-programmed computer that operates within a strict binary framework".<ref name="isbn0-618-61003-0">{{cite book |author=Groopman, Jerome E. |title=How Doctors Think |publisher=Houghton Mifflin Company |location= |year= |pages= |isbn=0-618-61003-0 |oclc= |doi=}}, quoted in Miles & al, 2007.</ref>''
''

==Future research==
As noted above (see '''Therapeutic uses, Cancer'''), the study of vitamin C [[pharmacokinetics]] not only triggered changes in the recommended dietary allowance of this vitamin, but it also raised interest in the [[cancer]]-killing properties of the molecule when it is administered intravenously. Once again, however, a closer look at the past will allow to open "new" (forgotten) therapeutic perspectives. Levine declared, "Nobody ever realized the difference between intravenous and oral. It's a huge difference. It's a medical-student, pharmacology 101 kind of error"<ref name="titleVitamin C research revives cure hopes"/> and underlined that it was justified to reopen the case about vitamin C in cancer because ''we'' are now aware of this "pharmacology 101 kind of error" that Pauling and Moertel altogether had committed.<ref name="pmid15068981"/>

However, a co-author of the same pharmacokinetic study disagrees: although Levine does not question the quality of the Mayo [[clinic study]] (and questions the value of Pauling and Cameron's study), Hugh Riordan declares the opposite: "The Mayo Clinic studies were done with the accepted experimental design used to clarify initial observations '''but did not truly replicate the Cameron and Pauling studies (used a lesser dosage,less time)'''. This issue has been reviewed elsewhere (''note: in Richardson, 1987'' <ref name="The Vitamin C and Cancer Controversy"/>)."<ref name="pmid15695476">{{cite journal |author=González MJ, Miranda-Massari JR, Mora EM, ''et al'' |title=Orthomolecular oncology review: ascorbic acid and cancer 25 years later |journal=Integr Cancer Ther |volume=4 |issue=1 |pages=32–44 |year=2005 |pmid=15695476 |doi=10.1177/1534735404273861}}</ref> In other words, Riordan co-signed a government-funded research where it is said that Pauling and Moertel were both wrong and that oral vitamin C is uneffective, but declares in another journal, with different co-authors and independently (practically at the same time), that oral administration is not wrong ''per se'', but that Mayo clinic's studies were, and refers to the famous sociological inquiry by Richardson published 15 years before to justify his claim. Manifestly, self-medication with (oral) vitamin C remains a politically sensitive issue.

'''Opportunity for major population-wide rises in vitamin C intakes'''

[[Image:Acerola.jpg|right|thumb|350px|{{#ifexist:Template:Acerola.jpg/credit|{{Acerola.jpg/credit}}<br/>|}}These acerola cherries contain more than 20 times more vitamin C than oranges by weight, and allow to reproduce the daily intake of other Higher Primates. According to current governemental recommendations, these doses (which are generally consumed in pill form) are "megadoses" and are either useless or dangerous.]]
In less favoured countries, the fear that the population could follow Pauling and colleagues and self-medicate with vitamin C is inexistant. While the myth that gram amounts of vitamin C are "megadoses" can be perpetuated in Northern countries where vitamin-C rich fruits are less common (worthy of note, [[rose hips | rose hips]], contain 20 times more vitamin C than commonly available fruits), in Southern Countries, fruits that provide such primate doses of vitamin C can be easily accessed. For instance, in Brazil, the nutritional data of a popular and affordable acerola juice indicates a content of vitamin C equivalent to ''15720'' % of the RDA per bottle (3144 % of the RDA per 100 ml). It is thus entirely possible that populations could raise their vitamin C intake by almost two orders of magnitude, without having to wait for any special permission or further costly studies.

'''Independent meta-analyses'''

The majority or trials with vitamin C use doses that are inferior to primate doses (less than a few grams, often a gram or less) and do not follow the proper dosing schedule (one or two admnistrations a day). Nonetheless, those are called trials of "high doses" because, from an anthropocentric and medicocentric point of view, these are doses that can only be afforded by the self-medicating populace -- galvanized by Pauling and his followers. Independent researchers will interpret the data for what they are worth, and take trials by Cathcart, Klenner, and others as the best currently available evidence. The fact that these authors were not made popular by the [[medico-academic industrial complex]], is an interesting sociopolitical consideration, but it is not relevant in the assessment of vitamin C's therapeutic value. The advent of [[open access journal | open access journals]] and, of course, authoritative online resources such as the [[Citizendium]], allow researchers to bypass the taboos imposed by publishing conglomerates where conflict of interests, by their own admission, is the rule rather than the exception. It is interesting to note that the critique of the most recent meta-analyses on vitamin C in the common cold has entered the scientific discourse by the door of a [[PLoS]] (Public Library of Sciences) journal. Steve Hickey later blowed the whistle about the fact that the [[Journal of Orthomolecular Medicine]], where Pauling and others published, is still rejected from the [[National Library of Medicine]] database, [[PubMed]], with no valid explanations given by the referees of the database (''ref'',''ref''). 

'''Neglected diseases and publications'''

The clinical and investigative works of Cathcart, Klenner, Jungeblut were made in a context of scarcity of resources that is not unlike the context in which the majority of clinicians throughout the world perform their work. The open access movement in sciences is viewed as an opportunity for clinicians and researchers to enter the scientific discourse by bypassing the systematic bias favouring the research agendas of [[developed country | developed countries]](ref). A major part of the world's [[burden of disease]] and of world's mortality is represented by [[infant mortality | infant deaths]]. Multitudes of clinicians and researchers from the [[Third World]] and other poorer countries will be interested to know how Frederick Klenner was able to achieve an exceptional record in this respect ''(ref + cf obstetrics and gynaecology)'', in a context quite similar to present-day Africa and Asia -- in the post-segregationist United States.

== References ==
<div class="references-small" style="-moz-column-count:2; column-count:2;">
<references />
</div>

== Working on these parts of the Vit C article ==
The initial version of the vit C page sections being worked on can be found [http://en.citizendium.org/wiki?title=User_talk:Pierre-Alain_Gouanvic&oldid=100247805 here]. 

All contributors can join the editing process, until this text looks less like my own editorializing and more like a fair report of the current critique! One may either edit directly, or raise problems here, in the talk page, preferably as a subsection. For example:
=== Eliminating "amateurism" and the like===
"Consecration of amateurism is vitamin C research" becomes "'''Ethical problems in the appraisal of vitamin C in health and disease'''". Some may argue it is not exactly neutral yet... I'll look if there is some better way summarizing this (heavy) section.
[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 13:39, 9 January 2008 (CST)

== Party!  You're invited! ==

Hi Pierre-Alain — Your neighbourhood Mistress of Ceremonies here.  Don’t forget to come on over to the [[CZ:Monthly Write-a-Thon|party]] and sign in at one of the categories!  [[User:Aleta Curry|Aleta Curry]] 16:39, 9 January 2008 (CST) [[user_talk:Aleta Curry|say ‘hi’ to me here]].

== CZ Live ==

Hi Pierre-Alain:  I just noticed in your recent [[vitamin C]] edit summary that you were trying to add a CZ Live tag.  To my knowledge, this is supposed to happen automatically once the metadata page is completed, so you may want to check with one of the admins if this isn't working properly. [[User:Aleta Curry|Aleta Curry]] 17:34, 12 January 2008 (CST)

== Please see... ==

Pierre, please see [[Talk:Financing_human_rights_and_full_employment]].  If you like, I can help suggest some ways you can transform this along the lines spoken about there.  Let me know.  Otherwise, it is going to need to be deleted soon, as discussed there. [[User:Stephen Ewen|Stephen Ewen]] 03:53, 13 January 2008 (CST)

== Personality disorder cycle ==

The personality disorder cycle is now complete.  Articles for all currently identified primary personality disorders have been added, along with internal references to the [[Personality disorder]], the [[Personality disorder#Cluster Descriptions|Cluster desriptions]], and a template detailing both the clusters, and their associated disorders.  Feel free to jump in! --[[User:Michael J. Formica|Michael J. Formica]] 08:15, 17 January 2008 (CST)

== reply ==

please see note on my talk page. [[User:Tom Kelly|Tom Kelly]] 14:19, 28 January 2008 (CST)

== Thanks ==

... for your kind words about the latest addition to the DPD article. (I [http://forum.citizendium.org/index.php/topic,1529.0.html posted to the forum] on this topic if you want to join in on the discussion.) It's nice to know my work is appreciated. :) And I need to return the thanks for collaborating and finding the article on cultural influences, as well as bringing up the philosophical connections. I look forward to continuing to work with you. --[[User:Richard Pettitt|Richard Pettitt]] 13:22, 30 January 2008 (CST)

== Mea culpa! ==

Pierre-Alain!  I just thought you'd remember it was [[CZ:monthly write-a-thon|party day]], but I don't see you in the crowd!  [[User:Aleta Curry|Aleta Curry]] 22:06, 6 February 2008 (CST)

== Internationalisation ==

Hi!  I’m just letting people who have expressed an interest in CZ International know that there is now a proposal on the table.

Please discuss its feasibility at: [[CZ:Proposals/Internationalisation sandbox]] in the Discussion area.

Feel free to help develop the proposal, as well.

We'll also need "drivers".

If you've got no idea what I'm talking about, please refer to: [[CZ:Proposals/New]] and [[CZ:Proposals]]

[[User:Aleta Curry|Aleta Curry]] 17:43, 14 February 2008 (CST)

::Hi again, Pierre-Alain.  Thank you very much for participating!  [[User:Aleta Curry|Aleta Curry]] 17:13, 15 February 2008 (CST)
:::Your last edit to your most recent comment was very useful.  [[User:Aleta Curry|Aleta Curry]] 15:21, 18 February 2008 (CST)
:::Thanks for signing on as driver.  I'll help. [[User:Aleta Curry|Aleta Curry]] 17:15, 20 February 2008 (CST)

Okay, more:

I've updated the proposal summary page at: http://en.citizendium.org/wiki/CZ:Proposals/Executive#Internationalisation_sandbox

see if you approve.  Feel free to change it as you see fit, I don't want to step on your toes.

I'm taking care of the mailings, and I've made the link at the Forum more prominent, I hope.

[[User:Aleta Curry|Aleta Curry]] 16:31, 21 February 2008 (CST)

== There's a party going on... ==

...and when you Euro kids wake, Pierre-Alain, it'll be Wednesday.

So join us!

It should be our usual [[CZ:monthly write-a-thon|madcap affair.]]

This month, our special theme is "Something you absolutely ''love''".  

Be there or be square!

[[User:Aleta Curry|Aleta Curry]] 15:58, 4 March 2008 (CST)

== Your proposal "Internationalisation sandbox" ==

Cher Pierre-Alain. The proposal record for "[[CZ:Proposals/Internationalisation sandbox|Internationalisation sandbox]]", for which you are listed as driver, says that the current step (request tekkie involvement, continue to generate discussion, begin deciding on details) was due to be completed 7 March. Could you please update the proposal record on [[CZ:Proposals/Executive]], changing your self-imposed deadline and perhaps the next step? If you have any questions, please do not hesitate to ask me. -- The Proposals Manager, [[User:Jitse Niesen|Jitse Niesen]] 09:22, 10 March 2008 (CDT)

== Nice to see you ==

Aha!  I see you're online.  Missed you at the last write-a-thon.  Good to see you.  [[User:Aleta Curry|Aleta Curry]] 17:50, 6 April 2008 (CDT)

== Breast Cancer Fund Report ==

Pierre-Alain: Regarding

[http://www.breastcancerfund.org/site/pp.asp?c=kwKXLdPaE&b=206137 State of the Evidence 2008: The Connection Between Breast Cancer and the Environment. Edited by Janet Gray, Ph.D., published by the Breast Cancer Fund. Free PDF Download]

Do you think the Breast Cancer Fund would allow CZ to reproduce the "Executive Summary" of their State of the Evidence 2008 report as an Addendum subpage to the section on environmental factors in our [[Breast cancer]] article, with the link to the full-report as above?

Do you have the contacts that would allow you to explore that?

If not an Addendum subpage, perhaps a Signed Article subpage, "Edited by Janet Gray, Ph.D., for the Breast Cancer Fund", again with the link to the site and full-report.

If they okay it, I'd volunteer to do the mechanics of getting it up on CZ.

--[[User:Anthony.Sebastian|Anthony.Sebastian]] 22:00, 7 April 2008 (CDT)

:Thanks, Pierre-Alain, for considering this and for writing to the editor.  I will await your report of her response, hopefully affirmative, before proceeding with the mechanics of incorporation. --[[User:Anthony.Sebastian|Anthony.Sebastian]] 16:16, 18 April 2008 (CDT)

::Pierre-Alain: I read you message on my Talk page re Janet's response. A giant step for womankind, but not through CZ.  Though it heartened me to hear you might find time to share what you learned in your translation work.  I, too, wish I could   find the time to do something for CZ from the report; study it thoroughly, summarize findings and advice. Perhaps we can recruit Nancy Evans to CZ authordom.  Thanks for your efforts.  --[[User:Anthony.Sebastian|Anthony.Sebastian]] 14:21, 29 April 2008 (CDT)

== Obesity ==

Pierre-Alain, thanks for calling your [[Obesity]] article to my attention. Well done, well-referenced.  I will read more carefully a second time soon and try to make specific comments.

You may know I started a subsection on obesity in [[Evolutionary medicine]] &mdash; http://en.citizendium.org/wiki?title=Evolutionary_medicine&action=edit&section=6.  I haven't worked on it in a while.  You stimulate me to get back to it.

You might take a look at reference 22 cited there, by Wisse et al.  I can send you a PDF if you need it.  --[[User:Anthony.Sebastian|Anthony.Sebastian]] 19:08, 15 May 2008 (CDT)
----
<br>
Pierre-Alain, my pardon.  I should have checked the history page before jumping into [[Obesity]].  --[[User:Anthony.Sebastian|Anthony.Sebastian]] 16:45, 16 May 2008 (CDT)

== Internationalisation ==

Hi Pierre-Alain,

I am wondering if you know when the Executive Committee will decide or not to follow your proposal to launch international initiatives. 

I've left wikipedia one year ago, because I could not bear anymore the anonymous equality among its users, but I am sad having written nothing since this day. I do not feel good enough in English to write long articles... Moreover, i think French is by far cuter ;)

Merci d'avance pour ta réponse camarade.

--[[User:Sylvain Catherine|Sylvain Catherine]] 13:17, 29 June 2008 (CDT)

== Please join us for Biology Week! ==

<table><tr valign=top><td>
Hello Pierre-Alain,

I am giving you this personal invitation to join us this week for Biology Week!

You're a ''Citizendium'' Biology Author and we need authors as much as editors here to get involved.  Did you know that there are over ''200'' biology authors here?  Yep!

Please join us on the wiki and add or revise biology articles.  Also, please let your friends and colleagues who are biologists, biology students, or naturalists, know about Biology Week and ask them to join us, too.  Any way you can help make it an event would be most welcome.  Think of it as a [[CZ:Biology Workgroup|Biology Workgroup]] open house.  Let's see if we can kick up activity a notch!

Thanks in advance! --[[User:Larry Sanger|Larry Sanger]] 13:09, 22 September 2008 (CDT)
</td><td>{{Biology open house}}</td></tr></table>

== water ==

Pierre, as I said, I'm prepared to detail some of my scientific criticism against the Roy paper. I don't know what the right place would be and I also don't know if we wouldn't stray away too far from CZ's objectives. But, if you're interested, I can give some details, not on the whole paper, that would take too much space, but on an example -- as a case study -- where Roy et al. clearly violate the established principles of scientific reporting. --[[User:Paul Wormer|Paul Wormer]] 03:23, 27 September 2008 (CDT)

:Pierre, thanx for your contributions to the homeopathy article! I saw your reference to that new movie on THE MYSTERY OF WATER.  Have you seen it yet?  Does it mention or highlight homeopathy?  How long is it?  

:In reference to the homeopathy article, as much as I am personally intrigued by Emoto's work, I do not believe that it has a place in the homeopathy article until there is some type of formal research on it.  

:Paul, I too will be interested in your critique of Roy's work on homeopathy, though less interested in his work on fire and salt water.  [[User:Dana Ullman|Dana Ullman]] 07:48, 1 October 2008 (CDT)

::In response to your question to my at my page, I trust you to do what you think is best.  I do, however, hope that you get a chance to read all or part of my new book.  It'll give you a lot of well-documented facts of history and research.  [[User:Dana Ullman|Dana Ullman]] 21:15, 1 October 2008 (CDT)

==CZ en français==
Bonjour, savez-vous où en est le projet de création de CZ en français ? Cordialement. [[User:Thierry Henri Cauchois|Thierry Henri Cauchois]] 18:49, 9 December 2008 (UTC)
=== French Wikipedia ===
Monsieur Gouanvic, jetez un oeil au site web, 'fr.wikipedia.org/wiki/Homeopathie' s'il vous plait.&mdash;[[User:Ramanand Jhingade|Ramanand Jhingade]] 03:45, 26 December 2008 (UTC)

==Paracelsus==
For future discussions:(from homeopathy's archive 8)

''I think that Martin's contribution was quite useful. I will reference to the Work of Peter Morell (historian of medicine, with training in homeopathy and conventional biology), "Hahnemann and Homoeopathy". 

:Book review: Novel ideas / findings in the book

:Hahnemann was reluctant to associate his new system of medicine with the name of Theophrastus or Paracelsus for fear of being misunderstood or being accused of plagiarism. (p. 15)

:The truth is of course, that Hahnemann was a second Paracelsus, but he felt he had to hide this fact. (p.72)

--Pierre-Alain Gouanvic 18:37, 7 December 2008 (UTC)''
--[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 17:37, 24 December 2008 (UTC)
* [http://www.homeoint.org/morrell/articles/esoteric.htm THE SECRETIVE HAHNEMANN AND THE ESOTERIC ROOTS OF HOMEOPATHY] by Peter Morrell
:--[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 03:43, 3 January 2009 (UTC)

==Fields==
Pierre, i don't have time to write immediately but this link gives a pretty good historical and contempory context.  http://8e.devbio.com/article.php?id=18  [[User:Chris Day|Chris Day]] 20:39, 24 December 2008 (UTC)

== Thank you ==

[http://en.citizendium.org/wiki?title=Talk%3AAlternative_medicine_%28theories%29&diff=100427734&oldid=100427716 That] was an honorable intervention on your part. [[User:D. Matt Innis|D. Matt Innis]] 17:16, 27 December 2008 (UTC)

==Anti-intellectualism==
http://74.125.95.132/search?q=cache:jVcLSLOi3KwJ:www.med.ufl.edu/oea/opfd/faculty/club_med/ebmarticle1.pdf+anti-intellectualism+evidence-based+medicine&hl=fr&ct=clnk&cd=18
--[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 08:41, 5 January 2009 (UTC)

== Restart of proposal system ==

Hello. Due to a lack of activity and attention on my part, the Proposal System has ground to a halt and discussion on all proposals has stopped. I decided to clean out the system by marking all proposals as inactive and removing their drivers. This also happened to your proposal [[CZ:Proposals/Internationalisation sandbox|"Internationalisation sandbox"]]. I would be delighted if you decide that you want to take the proposal up again. You can do this by updating the proposal record, which can now be found at [[CZ:Proposals/Driverless]]. Please do not hesitate to ask if anything is unclear. Yours, [[User:Jitse Niesen|Jitse Niesen]] 22:37, 23 February 2009 (UTC) (Proposals Manager)