Apolipoprotein C-III: Difference between revisions
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In [[medicine]] and [[physiology]], '''apolipoprotein C-III''' is [[apolipoprotein]] that is "a 9-kDa [[protein]] component of [[very-low-density lipoprotein]]s and [[chylomicron remnant]]s. Apo C-III, synthesized in the liver, is an inhibitor of [[lipoprotein lipase]]. Apo C-III modulates the binding of chylomicron remnants and VLDL to receptors ([[receptors, LDL]]) thus decreases the uptake of triglyceride-rich particles by the liver cells and subsequent degradation. The normal Apo C-III is glycosylated. There are several polymorphic forms with varying amounts of [[sialic acid]] (Apo C-III-0, Apo C-III-1, and Apo C-III-2)."<ref>{{MeSH}}</ref> | In [[medicine]] and [[physiology]], '''apolipoprotein C-III''' is [[apolipoprotein]] that is "a 9-kDa [[protein]] component of [[very-low-density lipoprotein]]s and [[chylomicron remnant]]s. Apo C-III, synthesized in the liver, is an inhibitor of [[lipoprotein lipase]]. Apo C-III modulates the binding of chylomicron remnants and VLDL to receptors ([[receptors, LDL]]) thus decreases the uptake of triglyceride-rich particles by the liver cells and subsequent degradation. The normal Apo C-III is glycosylated. There are several polymorphic forms with varying amounts of [[sialic acid]] (Apo C-III-0, Apo C-III-1, and Apo C-III-2)."<ref>{{MeSH}}</ref> | ||
Latest revision as of 09:42, 17 October 2010
In medicine and physiology, apolipoprotein C-III is apolipoprotein that is "a 9-kDa protein component of very-low-density lipoproteins and chylomicron remnants. Apo C-III, synthesized in the liver, is an inhibitor of lipoprotein lipase. Apo C-III modulates the binding of chylomicron remnants and VLDL to receptors (receptors, LDL) thus decreases the uptake of triglyceride-rich particles by the liver cells and subsequent degradation. The normal Apo C-III is glycosylated. There are several polymorphic forms with varying amounts of sialic acid (Apo C-III-0, Apo C-III-1, and Apo C-III-2)."[1]
Fatty liver and steatohepatitis may be caused by the single-nucleotide polymorphisms rs2854116 (c.455T>C) and rs2854117 (c.482C>T) of apolipoprotein C-III which are also associated with insulin resistance and hypertriglyceridemia.[2]
External links
References
- ↑ Anonymous (2024), Apolipoprotein C-III (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Petersen KF, Dufour S, Hariri A, Nelson-Williams C, Foo JN, Zhang XM et al. (2010). "Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease.". N Engl J Med 362 (12): 1082-9. DOI:10.1056/NEJMoa0907295. PMID 20335584. Research Blogging.